Metabolic blockages

What are the solutions for removing metabolic blockages ?

Basic metabolism is the reflection of our body’s proper functioning.

It orchestrates the transformation of nutrients into energy, regulates weight, digestion and body temperature, and is closely interdependent with overall health, hormonal balance and the immune system.

But in some women, particularly over 35 or in the case of hormonal imbalance, this system can go haywire: we speak of metabolic blockages. These slowdowns can be linked to hormonal imbalances (as in perimenopause or PCOS), low-grade inflammation, or poor sugar and energy management at cellular level.

The main symptoms? Slowed digestion, weight gain around the waist, insulin resistance, disturbed fat metabolism, hormonal imbalance, fatigue and reduced concentration…

At MiYé, we’ve designed a comprehensive, natural and innovative response that tackles the root causes of these metabolic blockages, which are particularly prevalent in PCOS, perimenopause and post-menopause.
Our formulas are developed with the best active ingredients from green biotechnology and without phytohormones, to be safe, compatible and effective for as many women as possible.

How can you boost your metabolism naturally?

To better understand metabolic blockages, we need to understand what prevents them from working properly, by looking at the root causes of these basic metabolic slowdowns: hormonal disorders, chronic stress, insulin resistance (often favoured by an excess of cortisol, the stress hormone), loss of muscle mass or liver overload in particular…

Targeted active ingredients to lift metabolic barriers

At MiYé, our dietary supplement [MY] Essentiels Activateur de Métabolisme acts at the root of these blockages thanks to a synergy of 9 natural and scientifically recognized active ingredients:

a) Hormonal regulation

• Myo-inositol: A natural compound that improves ovarian function and metabolic parameters in women with PCOS [1].
• Broccoli extract titrated in sulforaphane: Naturally provides phytochemical compounds, notably sulforaphane, studied for its role in balancing metabolic processes and modulating certain hormone receptors [2].
• Vitamin B complex (B3, B6, B9): We’ve combined a complex of essential B vitamins (B3, B6 and B9). Vitamins B3, B6 and B9 contribute to the normal functioning of the nervous system and help reduce fatigue. Vitamin B6 helps regulate hormonal activity and support normal energy metabolism. Vitamin B9 contributes to normal homocysteine metabolism.b) Cortisol regulation
• Magnesium: Traditionally used to support cellular energy and resistance to stress. It contributes to normal energy metabolism, helps reduce fatigue, supports normal nervous system function and maintains normal bone structure.
• Ashwagandha: Recognized for its many health benefits, particularly its adaptogenic action, which helps the body adapt to stress factors. Its main benefits include helping to reduce stress and anxiety by regulating stress hormones such as cortisol, optimizing sleep quality thanks to its relaxing effects, and improving brain function by enhancing memory and concentration [3].2) Sugar regulation

• Chromium: Helps maintain normal blood sugar levels and normal macronutrient metabolism.
• Gymnema: Ayurveda’s flagship plant, traditionally used to support glycemic balance. In vitro studies have shown that it can stimulate insulin release and reduce intestinal sugar absorption, helping to better manage glycemic peaks and sweet cravings [4].

3) Regulation of fat metabolism

• Matcha: Rich in catechins, notably EGCG (epigallocatechin gallate) and caffeine, matcha is known to stimulate thermogenesis and promote fat oxidation, particularly during moderate physical effort. Clinical studies have shown improved fat burning and lipid metabolism in overweight subjects or after regular consumption [5], [6].
• L-Carnitine: A naturally occurring amino acid traditionally used to support energy metabolism. Clinical studies have shown that it can promote fat oxidation during exercise and contribute to improved body composition, particularly in overweight people or those suffering from chronic muscle fatigue [7], [8].
• MCT coconut powder: MCT fatty acids (Medium Chain Triglycerides) promote rapid energy and metabolism [9].

4) Muscle loss

• Creatine monohydrate: An amino acid naturally present in our muscles, it plays a key role in the production of ATP, the main source of cellular energy.One study showed that creatine supplementation also facilitates muscle rehabilitation after a period of inactivity, by modulating the expression of muscle myogenic factors [10].

4) Liver support

• NAC (N-acetylcysteine): Precursor of glutathione, the body’s major antioxidant. Studied for its role in maintaining oxidative balance and supporting the liver’s natural detoxification functions [11].
• Broccoli extract titrated in sulforaphane: Source of phytochemical compounds, including sulforaphane, studied for its role in activating hepatic detoxification enzymes and modulating certain hormone receptors [12].
• Rosemary:Rosemary is a traditional adaptogen that is a veritable Swiss Army knife for our health [13].
  It is one of the most powerful natural antioxidants for combating oxidative stress. It is also a plant on which we have a lot of experience and publications. A particularly powerful antioxidant, it also helps stimulate digestion, relieve bloating and digestive cramps, and tone and detoxify the liver.
• Desmodium: Desmodium is a herbaceous plant prized in phytotherapy for its protective and regenerative effects on the liver.

It helps support liver function, protect liver cells and promote detoxification. This plant can help improve liver function by acting as a natural drainer, promoting better purification of the body. It is considered to have interesting potential for supporting liver function and the body’s detoxification process [14].

Signs of a blocked metabolism: how to recognize them ?

Metabolic blockages may be silent… but certain symptoms are revealing:

• Unexplained weight gain, especially around the belly
• Chronic fatigue or low energy
• Sweet cravings, hypoglycemia, difficulty stabilizing blood sugar levels
• Mental fog, concentration problems
• Bloating, slow digestion, slowed transit
• Heavy legs, water retention
• Irregular cycles, PCOS, premenopause or perimenopause

Our natural solutions for metabolic blockages are developed and manufactured in France;

Our natural solutions for metabolic blockages

At MiYé, we have developed a comprehensive approach that supports the metabolism at every stage:

Metabolism-activating supplement

Our [MY] Essentiels Metabolism Activator supplement contains key active ingredients to restore metabolic balance, acting on :

• sugar management,
• cellular and hepatic detox,
• oxidative stress,
• and energy fatigue.
  It is particularly suitable for women with PCOS, premenopause or insulin resistance.

Natural detox and digestion

Herbs such as rosemary, fennel or hibiscus (present in our formula) support digestion, drainage and the liver – often overloaded during a metabolic slowdown.

Sources :

[1] : Gerli S, Papaleo E, Ferrari A, Di Renzo GC. Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS. Eur Rev Med Pharmacol Sci. 2007;11(5):347–354. PMID: 18074950

 [2] : Ramirez MC, Singletary KW. Regulation of estrogen receptor α expression in human breast cancer cells by sulforaphane. J Nutr Biochem. 2009;20(3):195–201. doi:10.1016/j.jnutbio.2008.02.002. PMID: 18602823

[3] : MiYé. Ashwagandha [Internet]. Disponible sur : https://www.miye.care/glossaire/ashwagandha/

[4] : Persaud SJ et al. Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability. J Endocrinol. 1999;163(2):207–212. [PMID: 10556769]

[5] : Willems MET, Şahin MA, Cook MD. Matcha green tea drinks enhance fat oxidation during brisk walking in females. Int J Sport Nutr Exerc Metab. 2018 Sep;28(5):536–41. doi:10.1123/ijsnem.2017-0237. PMID: 29345213.

[6] : Gunnars K. Green Tea for Weight Loss: How it Works [Internet]. Healthline; 2025 Jan 7 [cité le 20 mai 2025]. Disponible sur: https://www.healthline.com/nutrition/green-tea-and-weight-loss?

[7] : Pooyandjoo M, et al. The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials. Obes Rev. 2016;17(10):970–976. [PMID: 27335245]

[8] : Wall BT, et al. Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans. J Physiol. 2011;589(Pt 4):963–973. [PMID: 21224233]

[9] : St-Onge MP, Bosarge A. Weight-loss diet that includes consumption of medium-chain triacylglycerol oil leads to a greater rate of weight and fat mass loss. Obes Res. 2003;11(3):395–402. [PMID: 12634436]

[10] : Hespel P, Op’t Eijnde B, Van Leemputte M, Ursø B, Greenhaff PL, Labarque V, Dymarkowski S, Van Hecke P, Richter EA. Oral creatine supplementation facilitates the rehabilitation of disuse atrophy and alters the expression of muscle myogenic factors in humans. J Physiol. 2001 Oct 15;536(Pt 2):625-633. doi:10.1111/j.1469-7793.2001.0625c.xd. PMID: 11600695; PMCID: PMC2278864.

[11] : Zafarullah M, Li WQ, Sylvester J, Ahmad M. Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci. 2003 Jan;60(1):6-20. doi:10.1007/s000180300001. PMID: 12613655; PMCID: PMC11138873.

[12] : Ahmad F.A., Iori R., Ioannides C. The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer. Int J Cancer. 2011;128(12):2775-82. PMID: 20726001

[13] : MiYé. Romarin [Internet]. Disponible sur: https://www.miye.care/glossaire/romarin/

[14] : MiYé. Desmodium [Internet]. Disponible sur: https://www.miye.care/glossaire/desmodium/