BONOLIVE®

BONOLIVE®

PRESERVES ⎪ FORTIFIES ⎪ PROTECTS

Bonolive® is a patented olive leaf extract standardized in oleuropein, recognized for its exceptional properties on bone health.
This active ingredient of Mediterranean plant origin offers a natural and innovative approach to preserve bone capital, particularly in women in perimenopause and menopause.

It works deeply to slow down bone breakdown and stimulate mineralization, helping to maintain bone density and strength over time.
Its complementary antioxidant and anti-inflammatory properties make it an active ingredient with a global action on the body.

What is Bonolive®? Definition and origin

Bonolive® is a patented ingredient developed by BioActor, extracted from olive leaves (Olea europaea L.), standardized to 40% oleuropein.
The olive tree, emblem of the Mediterranean basin since Antiquity, has been recognized for millennia for its multiple therapeutic virtues.

Oleuropein is the major polyphenol of the olive tree, responsible for most of its biological properties.
In the context of bone health, it acts on two complementary pathways: it inhibits osteoclasts (cells responsible for bone destruction) and stimulates osteoblasts (cells responsible for bone formation).

This dual mechanism is particularly valuable during menopause, a period during which the drop in estrogen accelerates bone remodeling to the detriment of density.
Clinical studies demonstrate that Bonolive® significantly reduces markers of bone resorption.

BioActor's proprietary extraction technology ensures precise oleuropein concentration and standardization, ensuring repeatable batch-to-batch effectiveness.
Bonolive® is part of a sustainable approach, using abundant and well-tolerated plant raw materials.

Composition and active ingredients

Bonolive® is standardized to offer an optimal concentration of olive polyphenols:

• Oleuropein (40%) major polyphenol with osteoprotective and antioxidant action
• Hydroxytyrosol metabolite of oleuropein with powerful anti-inflammatory properties
• Flavonoids associated with luteolin and apigenin with synergistic effects on bone
• Elenolic acid contributing to antimicrobial and anti-inflammatory activity
• Standardized total polyphenols guaranteeing reproducibility of effects

What are the benefits of Bonolive®?

Bonolive® stands out for its action on bone remodeling, a natural process which, when disrupted, leads to osteoporosis.
Its dual mechanism of action, inhibition of destruction and stimulation of formation, makes it particularly suitable for women whose bone stock is weakened by the drop in estrogens.

Its systemic antioxidant and anti-inflammatory effects also help protect joints and reduce low-grade inflammation frequently associated with menopause.
Its excellent tolerance and its plant origin make it a natural and well-accepted choice.

• Preserves bone mineral density by inhibiting bone resorption
• Stimulates osteoblast activity to promote bone formation
• Reduces biological markers of bone degradation
• Protects joints thanks to its anti-inflammatory properties
• Neutralizes oxidative stress thanks to its antioxidant polyphenols
• Supports cardiovascular health as a supplement
• Contributes to overall cellular protection
• Acts synergistically with calcium and vitamin K2 for optimal bone health

Key points:

• Clinically studied to reduce bone resorption markers
• Osteoprotective action via dual osteoblast/osteoclast mechanism
• Standardized at 40% oleuropein for guaranteed effectiveness
• Mediterranean plant origin, excellent tolerance
• Particularly suitable for women in perimenopause and menopause

Directions for use

Bonolive® is used as a food supplement at dosages generally between 250 and 500 mg per day.
It is recommended to combine it with sufficient intakes of calcium and vitamin D for an optimal effect on bone health.

For optimal use, include Bonolive® in a treatment of at least 3 months, in combination with a balanced diet and regular physical activity.
It can be taken at mealtimes to optimize digestive tolerance.

⚠️ Note: People on anticoagulant treatment should consult their doctor before use, due to the antioxidant properties of polyphenols.

Precautions for use

Adverse effects

Bonolive® benefits from an excellent tolerance profile, complying with the standards of Mediterranean plant extracts.
Adverse effects remain exceptional and generally limited to slight digestive disturbances at the start of the treatment.

⚠️ Not recommended for people allergic to Oleaceae. Consult a doctor in case of anticoagulant or anti-aggregant treatment. Pregnant and breastfeeding women should consult their healthcare professional.

Frequently asked questions

What are the benefits of Bonolive® on bones?
Bonolive® acts through a dual mechanism: it slows bone destruction by osteoclasts while stimulating the formation of new bone by osteoblasts, thus preserving bone mineral density.

Is Bonolive® suitable for menopausal women?
Yes, this is precisely the population for which it has been studied the most. The drop in estrogen at menopause accelerates bone resorption, and Bonolive® helps to slow down this phenomenon.

How to combine Bonolive® with other active ingredients?
It combines ideally with calcium bisglycinate, vitamin D3 and vitamin K2 for comprehensive support of bone health.

How long does it take to see effects?
Biological markers of bone resorption begin to change after 4 to 8 weeks. Treatments of at least 3 months are recommended for lasting effects.

Does Bonolive® have benefits other than on bones?
Yes, its antioxidant and anti-inflammatory properties give it protective effects on the joints and the cardiovascular system.

Sources

• Calcified Tissue International "Olive polyphenols and bone health: a systematic review" (2018)
• BioActor Bonolive® clinical file (2021)
• Phytotherapy Research "Oleuropein supplementation and bone metabolism" (2020)