PYRIDOXAL 5'-PHOSPHATE: The active form of vitamin B6, essential for skin and hormonal balance

REGULATES | DETOXIFIES | BALANCES

What is pyridoxal 5'-phosphate ?

THEpyridoxal 5'-phosphate(also calledP-5-P) is thebiologically active form ofvitamin B6, essential for more than 140 enzymatic reactions in the body. Unlike "standard" vitamin B6 (pyridoxine), P-5-P is directlyassimilable and usable by cells, making it a valuable form for hormonal regulation, skin health and overall metabolism.

It plays a central role in the synthesis of neurotransmitters (dopamine, serotonin), protein metabolism and the regulation of inflammation. In cosmetics or supplementation, P-5-P is used forcalm skin imbalances linked to stress or hormonal fluctuations, especially in skin prone to acne or chronic inflammation.

Where does pyridoxal 5'-phosphate come from ?

Vitamin B6 comes in several forms: pyridoxine, pyridoxamine, and pyridoxal.pyridoxal 5'-phosphateis theactivated form, produced by the liver from these precursor forms. In supplementation, it is generally ofvegetable or synthetic, for optimal stability. Unlike pyridoxine (often poorly metabolized in some people), P-5-P bypasses enzyme deficiencies and acts immediately.

Properties and active ingredients

Pyridoxal 5'-phosphate is asystemic regulator, particularly useful in skin, emotional and metabolic problems:

• Hormonal and nervous regulator: Reduces symptoms related to premenstrual syndrome (PMS), balances cortisol and improves stress tolerance, often reflected on the skin.
• Liver detox support: Facilitates the elimination of used hormones and toxins responsible for skin breakouts.
• Anti-inflammatory: Reduces chronic inflammatory conditions, including those affecting the skin (eczema, inflammatory acne).
• Synthesis of collagen and keratin: Contributes to the health of connective tissues, nails, hair and skin.
• Improves mood and sleep: Via the conversion of tryptophan into serotonin and melatonin, key elements of psychocutaneous balance.

What are the benefits of pyridoxal 5'-phosphate ?

✔ Regulates hormonal imbalances and their effects on the skin
✔ Calms skin prone to hormonal acne or stress
✔ Promotes better hepatic (liver) detox
✔ Supports energy production and overall vitality
✔ Participates in collagen synthesis, for firm skin and a luminous complexion

How to consume or use pyridoxal 5'-phosphate ?

The P-5-P is mainly used infood supplement:

• Recommended dosage: Between10 and 50 mg per day, according to individual needs (stress, hormonal disorders, chronic fatigue, acne, etc.)
• Combined formulations: Often combined with magnesium, taurine or zinc to enhance its effects on the nervous system and skin.
• Cosmetics (emerging): Rare dermocosmetic formulas are beginning to incorporate P-5-P for its anti-inflammatory and soothing properties.

⚠️ Always consult a healthcare professional before supplementation, especially in case of medical treatment or pregnancy.

Any side effects ?

The P-5-P isgenerally very well tolerated:

• Rare side effects at normal dose
• At high doses (> 100 mg/day), possibility of reversible tingling or paresthesia
• Possible interaction with certain medications (particularly antiepileptics)

Sources

• Impact on skin and pigmentation
  Vitamin B6 (including PLP) suppresses phagocytosis of melanosomes by keratinocytes through activation of Nrf2, preventing pigment spotsjstage.jst.go.jp.
• Major systemic role
  Vitamin B6 / PLP plays a central role in overall cellular metabolism, affecting oxidative stress, immunity, and cellular homeostasis.en.wikipedia.org+9lpi.oregonstate.edu+9cosmeticsinfo.org+9
• Inflammation regulator and skin biomarkers
  Low PLP levels are associated with elevated inflammatory markers. Increased P5P reduces the activation of PYGL and G6PD enzymes involved in skin inflammation.en.wikipedia.org+3sciencedirect.com+3consensus.app+3.