PYRIDOXAL 5’-PHOSPHATE

PYRIDOXAL 5’-PHOSPHATE: The active form of vitamin B6, essential for skin and hormonal balance

REGULATES | DETOXIFIES | BALANCE

What is pyridoxal 5'-phosphate?

The pyridoxal 5’-phosphate (also called P-5-P) is the biologically active form of vitamin B6, essential for more than 140 enzymatic reactions in the body. Unlike "standard" vitamin B6 (pyridoxine), P-5-P is directly assimilated and usable by cells, making it a valuable form for hormonal regulation, skin health and overall metabolism.

It plays a central role in the synthesis of neurotransmitters (dopamine, serotonin), protein metabolism and the regulation of inflammation. In cosmetics or as a supplement, P-5-P is used to calm skin imbalances linked to stress or hormonal fluctuations, especially in skin prone to acne or chronic inflammation.

Where does pyridoxal 5’-phosphate come from?

Vitamin B6 comes in several forms: pyridoxine, pyridoxamine and pyridoxal. The pyridoxal 5’-phosphate is there activated form, produced by the liver from these precursor forms. In addition, it is generally of origin vegetable or synthetic, for optimal stability. Unlike pyridoxine (often poorly metabolized in some people), P-5-P bypasses enzyme deficiencies and acts immediately.

Properties and active ingredients

Pyridoxal 5'-phosphate is a systemic regulator, particularly useful in skin, emotional and metabolic problems:

• Hormonal and nervous regulator : Reduces symptoms related to premenstrual syndrome (PMS), balances cortisol and improves stress tolerance, often reflected on the skin.
• Liver detox support : Facilitates the elimination of used hormones and toxins responsible for skin rashes.
• Anti-inflammatory : Reduces chronic inflammatory conditions, including those that affect the skin (eczema, inflammatory acne).
• Synthesis of collagen and keratin : Participates in the health of connective tissues, nails, hair and skin.
• Improves mood and sleep : Via the conversion of tryptophan into serotonin and melatonin, key elements of psychocutaneous balance.

What are the benefits of pyridoxal 5’-phosphate?

✔ Regulates hormonal imbalances and their skin effects
✔ Calms skin prone to hormonal acne or stress
✔ Promotes better hepatic (liver) detox
✔ Supports energy production and overall vitality
✔ Participates in the synthesis of collagen, for firm skin and a luminous complexion

How to consume or use pyridoxal 5’-phosphate?

The P-5-P is mainly used in food supplement :

• Recommended dosage : Between 10 and 50 mg per day, according to individual needs (stress, hormonal disorders, chronic fatigue, acne, etc.)
• Combined formulations : Often combined with magnesium, taurine or zinc to enhance its effects on the nervous system and the skin.
• Cosmetics (emerging) : Rare dermocosmetic formulas are beginning to incorporate P-5-P for its anti-inflammatory and soothing properties.

⚠️ Always consult a healthcare professional before supplementation, especially in the event of medical treatment or pregnancy.

Any side effects?

The P-5-P is generally very well tolerated :

• Rare side effects at normal dose
• At high doses (> 100 mg/day), possibility of tingling or reversible paresthesias
• Possible interaction with certain medications (especially antiepileptics)

Sources

• Impact on the skin and pigmentation
  Vitamin B6 (including PLP) suppresses phagocytosis of melanosomes by keratinocytes through activation of Nrf2, preventing pigment spots jstage.jst.go.jp.
• Major systemic role
  VitaminB6/PLP plays a central role in overall cellular metabolism, affecting oxidative stress, immunity, and cellular homeostasis en.wikipedia.org+9lpi.oregonstate.edu+9cosmeticsinfo.org+9
• Inflammation regulator and skin biomarkers
  Low PLP levels are associated with elevated inflammatory markers. Increased P5P reduces activation of PYGL and G6PD enzymes involved in skin inflammation en.wikipedia.org+3sciencedirect.com+3consensus.app+3.