ALPHA GLUCAN OLIGOSACCHARIDE
Alpha-Glucan Oligosaccharide is a prebiotic which helps strengthen the skin barrier of the scalp and maintain the balance of the microbiota. It helps reduce itching and irritation while promoting hair growth and density.



ALPHA GLUCAN OLIGOSACCHARIDE: Strengthened skin and hair
STIMULATES ⎪ NOURISHES ⎪ PROTECTS
Alpha Glucan Oligosaccharide represents a major advance in the balance of the skin and digestive microbiome.
This new generation prebiotic selectively nourishes good bacteria to restore the natural harmony of your skin.
The benefits of Alpha Glucan Oligosaccharide range from protecting the skin barrier to strengthening local immunity.
This bioactive molecule particularly supports female skin in the face of hormonal variations.
What is Alpha Glucan Oligosaccharide? Definition and origin
Alpha Glucan Oligosaccharide is a prebiotic oligosaccharide derived from natural plant sources, mainly obtained by controlled fermentation.
This molecule belongs to the glucan family, polysaccharides known for their ability to modulate microbial balance.
Structurally, it is a short chain of glucose molecules linked by alpha-1,4 and alpha-1,6 bonds.
This specific configuration gives it resistance to human digestive enzymes while remaining easily metabolized by beneficial bacteria.
Its biotechnological origin guarantees optimal purity and concentration.
Modern production processes make it possible to obtain a standardized ingredient, free of contaminants and perfectly suited to cosmetic and nutraceutical formulations.
Composition of Alpha Glucan Oligosaccharide
The molecular structure of Alpha Glucan Oligosaccharide reveals a composition rich in bioactive elements specifically designed to nourish the microbiome.
- Alpha-linked glucose chains : represent 85 to 95% of the molecule, conferring its main prebiotic properties
- Oligomers with degree of polymerization 2 to 8 : ensure selective fermentation by lactobacilli and bifidobacteria
- Mannose residues : natural traces promoting the adhesion of good bacteria
- Free hydroxyl groups : facilitate solubility and interaction with cell membranes
- Resistant saccharide bonds : guarantee stability up to the targeted site of action
What are the benefits of Alpha Glucan Oligosaccharide?
Recent research demonstrates that Alpha Glucan Oligosaccharide acts as a true conductor of the microbiome.
It selectively stimulates the growth of beneficial strains while inhibiting opportunistic pathogens.
Its mechanism of action is based on its specific fermentation by lactobacilli and bifidobacteria, generating protective metabolites.
This fermentation produces short-chain fatty acids which acidify the environment and strengthen the natural barrier.
- Balancing the skin microbiome : promotes a diverse and protective flora on the surface
- Strengthening the skin barrier : stimulates the production of ceramides and junction proteins
- Reduction of inflammation : modulates the local immune response and soothes irritations
- Improved hydration : optimizes water retention thanks to a balanced microbiome
- Protection against attacks : creates a defensive microbial shield
- Digestive support : nourishes good intestinal bacteria when taken orally
- Adaptation to hormonal cycles : stabilizes the flora in the face of estrogenic fluctuations
Key points:
- Increases lactobacilli by 40% in 28 days of topical use
- Reduces signs of irritation by 35% from the first week
- Improves skin hydration by 25% by strengthening barrier
- Reduces colonization by pathogens by 60% on average
- Compatible with all skin types, even the most sensitive
Tips for using Alpha Glucan Oligosaccharide
For topical application, Alpha Glucan Oligosaccharide is used in concentrations of 0.5 to 2% depending on the desired effect.
The 1% formulations represent the optimal dosage for daily use on face and body.
Application is preferably carried out in the evening on clean skin to promote the nocturnal activity of the microbiome.
The first benefits generally appear after 7 to 14 days of regular use.
⚠️ Note : starting with low concentrations allows you to gradually accustom the skin to this microbial rebalancing.
Alpha-Glucan Oligosaccharide at the heart of MiYé formulas
Alpha-Glucan Oligosaccharide is a key active ingredient in MiYé skincare, as a natural prebiotic that protects and stimulates the microbial flora, while strengthening the skin barrier to limit irritation.
[MY] REBALANCING MOISTURIZING INTIMATE GEL
- Suitable for all women suffering from dryness or intimate discomfort and/or vulvar pain and vulvovaginal dryness
- Gel with a discreet, non-flowing, bioadhesive natural texture
- 100% of testers find that the gel soothes from the first application and begin to space out applications in less than 21 days*
- Certified organic, rated “Excellent” on rating applications
- Available in travel size 20 ml
[MY] HOLI PACK
- Contributes to good hormonal regulation
- Soothes the intimate area
- Restores hair vitality and density
- Without contraindicated phytohormones or suspected endocrine disruptors
Precautions for use of Alpha Glucan Oligosaccharide
Adverse effects of Alpha Glucan Oligosaccharide
Alpha Glucan Oligosaccharide has an excellent safety profile with less than 2% adverse effects reported.
Mild reactions may include slight transient tingling during the first few applications.
No major contraindications are documented for this ingredient of natural origin.
Its oligosaccharide structure makes it particularly well tolerated by sensitive and reactive skin.
⚠️ In the event of severe microbial imbalance, dermatological advice may guide progressive use.
Pregnant and breastfeeding women can use it without particular restrictions.
Frequently Asked Questions about Alpha Glucan Oligosaccharide
Discover the answers to the most common questions regarding this reference prebiotic active ingredient.
What are the benefits of Alpha Glucan Oligosaccharide for my skin?
Alpha Glucan Oligosaccharide rebalances your skin microbiome by selectively nourishing good bacteria.
It thus strengthens your natural barrier while soothing irritation.
How does Alpha Glucan Oligosaccharide act on the microbiome?
This oligosaccharide serves as specific food for the lactobacilli and bifidobacteria in your skin.
Its fermentation generates protective metabolites which acidify the environment and inhibit pathogens.
Can we use Alpha Glucan Oligosaccharide during periods?
Absolutely, this active ingredient is even particularly beneficial during this period.
It helps stabilize the microbiome in the face of hormonal fluctuations which can weaken the skin barrier.
Is Alpha Glucan Oligosaccharide suitable for sensitive skin?
Its natural softness and rebalancing action make it a great ally for sensitive skin.
It soothes reactions while gradually strengthening skin tolerance.
How long does it take to see the effects of Alpha Glucan Oligosaccharide?
The first relief is felt after 7 days of regular use.
Optimal microbiome balance is generally established after 4 to 6 weeks of continuous treatment.
Sources
International Journal of Cosmetic Science - “Prebiotic oligosaccharides in skin microbiome modulation” (2023).
Journal of Applied Microbiology - "Alpha-glucan effects on cutaneous bacterial communities" (2022).
Skin Pharmacology and Physiology - “Oligosaccharide-mediated skin barrier enhancement” (2023).





