Organic Ashwagandha KSM-66: What are the benefits of this renowned extract?

Understanding KSM-66 Ashwagandha

What is KSM-66 Ashwagandha ?

KSM-66 is a branded, full-spectrum extract derived exclusively from ashwagandha roots—specifically from Withania somnifera, the plant's scientific name. Unlike many other supplements, KSM-66 offers the highest concentration of root-only extracts available today, with over 5% withanolides concentration measured by HPLC. These withanolides are the key bioactive compounds responsible for its stress-relieving and sleep-enhancing effects.

What makes KSM-66 unique is its full-spectrum nature, meaning it retains all the natural constituents of the herb in their original balance. This holistic approach preserves the synergistic benefits that have made ashwagandha a cornerstone of traditional Ayurvedic medicine for centuries.

Developed by Ixoreal Biomed, KSM-66 is the product of 14 years of dedicated research and innovation. The company’s commitment to quality is unmatched, as it is the only ashwagandha manufacturer in the world with complete vertical integration. They own their farms, production facilities, testing laboratories, research center, and distribution network, ensuring consistent quality and rigorous testing of the final product.

The Unique Extraction Process

The secret behind KSM-66 lies in its proprietary extraction methodology, which adheres to "Green Chemistry" principles. Unlike conventional methods, this process does not use alcohol or synthetic solvents.

Instead, it employs an aqueous-based approach combined with traditional methods and modern distillation technologies to achieve the optimal balance. The process starts with ashwagandha roots cultivated on company-owned farms in Rajasthan, India, a region renowned for ashwagandha cultivation. After harvesting, the roots undergo strict quality control, including testing for 525 pesticides, are washed in purified water, dried in warm air ovens, and pulverized to a specific particle size for extraction.

What sets this process apart is its ability to preserve the plant's integrity. The roots are soaked in water for about 8 hours during the cold extraction phase, followed by a secondary hot extraction process. Throughout this multi-stage extraction, all the fibers and active principles of the plant are retained, avoiding the loss commonly seen in other methods. The final product is standardized to 5% withanolide concentration, ensuring consistency in every batch.

Why Opt for KSM-66 over Other Forms ?

When considering ashwagandha supplements, you'll find various options, from raw powders to liquid extracts to standardized formulations. KSM-66 stands out for several compelling reasons.

First, its full-spectrum nature ensures you're getting the complete botanical profile rather than isolated compounds. Research suggests this provides superior benefits compared to fractionated extracts. Whole extracts, which retain all the plant's constituents in their natural balance, tend to deliver more comprehensive effects than highly purified alternatives.

Another major advantage is the extensive clinical evidence supporting KSM-66. It boasts the most comprehensive research and clinical trials of any ashwagandha product available, with 48 double-blind randomized placebo-controlled trials demonstrating its efficacy and safety. This level of scientific validation is rare in the supplement industry and provides confidence in its reliability.

Additionally, KSM-66 offers practical benefits over other ashwagandha extracts. It has a neutral taste, avoiding the bitterness often associated with ashwagandha, making it easier to incorporate into your daily routine. Its superior bioavailability means your body can absorb and utilize the active compounds more efficiently, maximizing the supplement's benefits.

When investing in a supplement to support stress management and sleep quality, choosing a product like KSM-66—meticulously crafted, extensively researched, and scientifically validated—ensures you get real, measurable results.

The health benefits of Ashwagandha KSM-66®

Stress and anxiety reduction

Studies show that KSM-66® helps reduce levels of cortisol , the stress hormone, while promoting better emotional balance.

Clinical study (Chandrasekhar K. et al., 2012): 600 mg/day of KSM-66® for 60 days reduced cortisol by an average of 27% and significantly decreased anxiety and nervousness .

Indian J Psychol Med. 2012;34(3):255-262

In our [MY] Essentials Feminine Balance supplement, KSM-66® works in synergy with organic lemon balm and organic rosemary to soothe nervous tension, calm agitation and promote lasting serenity throughout the cycle.

Immune function support

Thanks to its richness in antioxidants and withanolides, KSM-66® helps protect cells against oxidative stress and supports natural defenses.

Scientific review: Frontiers in Pharmacology (Bhat JA et al., 2022) confirmed the immunomodulatory and anti-inflammatory role of ashwagandha (DOI: 10.3389/fphar.2022.1029123 ).

In [MY] Essentials Feminine Balance , rosemary reinforces this antioxidant and hepato-protective action, supporting the hormonal detoxification functions of the liver, a key organ for feminine balance.

Improved sleep quality

By acting on GABA receptors, a neurotransmitter of relaxation, KSM-66® promotes deep and restorative sleep.
Clinical study: Langade D. et al. ( Cureus , 2019) demonstrated a significant improvement in sleep after 8 weeks of supplementation (300 mg morning and evening) (DOI: 10.7759/cureus.5797 ).

At MiYé, we have formulated [MY] Essential Feminine Balance so that each ingredient supports the sleep-wake cycle:

• Ashwagandha KSM-66® calms the nervous system.
• Organic lemon balm reduces agitation.
• Vitamin B6 regulates hormonal activity.

The result: falling asleep more naturally and waking up feeling lighter.

Effects on physical and mental performance

On a physical and mental level, KSM-66® also acts as a natural nootropic: it improves memory, concentration and mental stamina.
Choudhary D. et al. (2017) showed an improvement in working memory and information processing speed after 8 weeks of supplementation ( J Diet Suppl. 2017;14(6):599–612 ).

In terms of physical performance, Wankhede S. et al. (2015) observed an increase in muscle strength and recovery after 8 weeks at 600 mg/day ( J Int Soc Sports Nutr. 2015;12:43 ).

Fatigue, brain fog or decreased concentration before menstruation or during perimenopause?
The ashwagandha + vitamins B9-B12 duo from [MY] Essentials Feminine Balance helps restore lasting mental clarity while reducing nervous strain.

Benefits for sexual health

The KSM-66® also supports sexual vitality and hormonal regulation.
Study: Lopresti AL et al. ( Am J Men's Health , 2019) observed an increase in testosterone and DHEA-S levels, two key hormones for energy and libido ( DOI: 10.1177/1557988319835985 ).

In women, KSM-66® helps regulate hormonal fluctuations responsible for decreased libido, hot flashes, and sleep disturbances.
This is why it is at the heart of the [MY] Essentials Feminine Balance formula, specifically designed to soothe hormonal variations without phytohormones.

How does Ashwagandha KSM-66 work on the body?

Mechanisms of action

Ashwagandha KSM-66 works primarily by modulating the stress response system, specifically by regulating cortisol levels , a hormone often associated with stress. By lowering cortisol levels, it helps the body regain emotional balance while improving sleep quality . Withanolides, its main active compounds, also possess neuroprotective properties , which help reduce anxiety and enhance essential cognitive functions such as memory and concentration .

The KSM-66® acts on several levels:

• Nervous system: GABA balance and cortisol reduction
• Hormonal system: modulation of stress, sleep, and metabolism hormones.
• Immune system: reduction of chronic inflammation and cellular protection.

Its adaptogenic action allows it to adapt to the body's needs: soothing in case of overwork, energizing in case of fatigue, balancing during hormonal variations.

Comparison with other forms of ashwagandha

Not all forms of ashwagandha are created equal. Several types of extracts are available on the market today, the best known of which are KSM-66®, Sensoril® and Shoden®.
Their difference lies mainly in the part of the plant used, the extraction process, and the profile of the active ingredients.

• KSM-66®:
  
  
• Made exclusively from the roots, as per Ayurvedic tradition,
• Extraction without chemical solvents, using a water and milk-based process (green chemistry),
• It retains the full spectrum of natural withanolides, ensuring a balanced action: both soothing and revitalizing,
  
  
• Standardized to 5% withanolides, the optimal dosage for daily use, without overstimulation.
• Supported by over 70 clinical studies proving its effectiveness on stress, sleep, memory, physical performance and libido.
  
  
• Sensoril®:
  
  
• Contains a mixture of leaves and roots, which alters the profile of the active ingredients.
  
  
• More concentrated (up to 10% withanolides), but less balanced: it acts more as a sedative than as an adaptogenic tonic.
  
  
• Some people report increased fatigue with prolonged use.
  
  
• Shoden®:
  
  
• Extract mainly from leaves, obtained by hydroalcoholic extraction.
  
  
• Rich in withanolide glycosides, effective in stress management, but with lower bioavailability than KSM-66®.
  
  

Thus, KSM-66® is considered the most balanced and complete form, as it acts on relaxation, mental clarity and energy, without side effects related to drowsiness.

This is why MiYé chose KSM-66® Bio to formulate [MY] Essentials Feminine Balance : a pure extract, gentle on the body, highly bioavailable and scientifically validated for its effects on hormonal and emotional regulation.

Usage tips

Recommended dosage

Clinical studies conducted on KSM-66® show that beneficial effects on stress, sleep and concentration appear from 300 to 600 mg per day.

This dosage, usually divided into two doses (morning and midday), allows for maximum effectiveness without causing drowsiness.

For a calming and stress-regulating effect, 300 mg/day is sufficient.

For complete action on fatigue, concentration and sleep, a dose of 600 mg/day is recommended; this dose is present in [MY] Essentials Feminine Balance .

Studies (Chandrasekhar K. et al., 2012; Langade D. et al., 2019) show that the results are significant after 8 to 12 weeks of daily intake, with an average reduction in cortisol of 25 to 30%.

Note: KSM-66® is an adaptogenic herb. Its effectiveness relies on regular and continuous intake, rather than occasional use.

When and how should I take it ?

KSM-66® can be consumed at any time during the menstrual cycle, but its benefits are particularly pronounced during periods of physical, mental, or hormonal fatigue:

• before menstruation (premenstrual syndrome),
• during perimenopause,
• after a period of intense stress,
• or during seasonal transitions.

In the form of a dietary supplement, it is recommended to take it:

• in the morning and at midday, preferably with a meal,
• and to avoid taking it in the evening for people who are very sensitive to its revitalizing effects.
  

In the [MY] Essentials Feminine Balance supplement, KSM-66® is combined with lemon balm, rosemary and vitamins B9, B12 and D3 to act on the three essential axes of feminine balance:

1. Regulating hormonal fluctuations,
2. To soothe stress and nervous tension,
3. Improve sleep quality and mental clarity.
   
   

The MiYé routine:

Take 4 tablets per day, 2 tablets in the morning and 2 at midday (to be swallowed or crushed with the back of a spoon and mixed into your drink according to your preference).

You can start taking it at any time during your cycle, ideally at least 2 weeks before your period.

We recommend taking it for 3 months (2 to 3 complete cycles) for optimal results.

Next, take a break for a few weeks to see how long the effects last and resume when the need arises.

Tip: Start your treatment two weeks before your period for optimal relief from hormonal symptoms (fatigue, irritability, sleep disturbances).

Potential interactions and contraindications

Although KSM-66® is very well tolerated, it is advisable to seek medical advice if you are undergoing thyroid treatment.

ANSES has identified only two isolated cases of transient hyperthyroidism between 2005 and 2022, with no link to KSM-66®.

No adverse effects were observed in clinical studies conducted with this extract.

Choose your KSM-66® Ashwagandha supplement

Quality and certification

Not all ashwagandha supplements are created equal. The quality of an extract depends on its traceability, purity, extraction method, and concentration of active ingredients.

The KSM-66® extract is now recognized as the global benchmark for its scientific and ethical excellence:

• 100% root, without leaves, to avoid the presence of irritating withanolides,
  
  
• Patented extraction process using water and milk, without chemical solvents, respecting Ayurvedic tradition.
  
  
• Standardized titration to 5% withanolides, for consistent efficacy.
  
  
• 46 international certifications (ISO, HACCP, GMP, USDA Organic, Non-GMO, Vegan),
  
  
• More than 70 clinical studies validate its safety and effectiveness on stress, memory, sleep and vitality.
• This high level of traceability ensures purity and reproducibility of results from batch to batch, an essential point in the field of natural food supplements.

At MiYé, we have selected this premium extract, in organic form and standardized to 5%, to guarantee the same quality as that used in clinical trials.

Quality and certification

The quality of an ashwagandha supplement also depends on its origin and method of manufacture.

A good product must come from a traceable and sustainable supply chain, be formulated in synergy with other natural active ingredients, and be manufactured according to French safety and quality standards (GMP).

That is why MiYé chose to formulate [MY] Essentials Feminine Balance in France, with organic plants, certified KSM-66®, and natural vitamins to guarantee purity, effectiveness and tolerance.

A formula designed for the female metabolism, without phytohormones, and supporting the three pillars of balance:

• Mental serenity
• Hormonal regulation
• Restful sleep

The essentials about KSM-66 ashwagandha

Ashwagandha KSM-66 is an exceptional natural supplement, renowned for its benefits in stress management , improved sleep quality , and support for physical and mental health . Thanks to its high quality, certified organic and vegan, and a gentle extraction process, this product stands out for its effectiveness, validated by rigorous clinical studies .

At MiYé, we have chosen to integrate this pure and organic extract into our [MY] Essentials Feminine Balance formula, to offer comprehensive support against the daily "hormonal storms": PMS, PCOS, perimenopause or simple mental overload.

Take care of your inner balance with a natural, hormone-free, effective and clinically proven solution.
Discover [MY] Essentials Feminine Balance on miye.care and rediscover the serenity your body needs.

FAQ

What are the main natural benefits of organic Ashwagandha KSM-66 for well-being?

Organic Ashwagandha KSM-66, rich in withanolides, is known for its numerous benefits. It helps reduce stress and anxiety, while improving sleep quality without causing dependency. This supplement also supports emotional balance, memory, concentration, and physical vitality. Furthermore, it boosts energy, combats fatigue, and offers antioxidant and anti-inflammatory properties, thus promoting better overall health.

Does taking Ashwagandha KSM-66 organic have any side effects or contraindications?

Taking organic Ashwagandha KSM-66 may cause side effects such as digestive problems, drowsiness, or allergic reactions. It is not recommended for pregnant or breastfeeding women, or for people with hyperthyroidism or liver problems. It is essential to adhere to the recommended dosage to avoid any risks.

How long does it take to feel the effects of organic Ashwagandha KSM-66 after starting to take it?

The effects of organic Ashwagandha KSM-66 are generally noticeable after 2 to 4 weeks of daily use. However, some people may experience improved sleep or a feeling of relaxation as early as the first weekend. Significant stress reduction often takes between 4 and 8 weeks.

Is organic Ashwagandha KSM-66 compatible with other supplements or medical treatments?

Organic Ashwagandha KSM-66 may interact with certain medications. For example, it may potentiate the effects of anticoagulants, excessively lower blood pressure or blood sugar, enhance the effects of sedatives, and interfere with thyroid or immunosuppressant treatments. It is strongly recommended that you consult a doctor before combining this supplement with other treatments.