PYRIDOXAL 5’-PHOSPHATE

PYRIDOXAL 5’-PHOSPHATE : La forme active de la vitamine B6, essentielle à l’équilibre cutané et hormonal

ÉRÉGULE | DÉTOXIFIE | ÉQUILIBRE

What is Pyridoxal 5’-Phosphate ?

Pyridoxal 5’-phosphate (also known as P-5-P) is the biologically active form of vitamin B6, required for over 140 enzymatic reactions in the body. Unlike the standard form (pyridoxine), P-5-P is directly usable by cells, making it especially valuable for hormonal regulation, skin health, and overall metabolism.

It plays a central role in the synthesis of neurotransmitters (dopamine, serotonin), protein metabolism, and inflammation regulation. In skincare and supplementation, P-5-P is used to soothe skin imbalances linked to stress or hormonal fluctuations, particularly in acne-prone or chronically inflamed skin.

Where does Pyridoxal 5’-Phosphate come from ?

Vitamin B6 exists in several forms: pyridoxine, pyridoxamine, and pyridoxal. Pyridoxal 5’-phosphate is the active form, produced by the liver from these precursors. In supplements, it is typically plant-based or synthetic for optimal stability. Unlike pyridoxine (which some individuals poorly metabolize), P-5-P bypasses enzymatic deficiencies and acts immediately.

Properties and Active Benefits

Pyridoxal 5’-phosphate is a systemic regulator, especially helpful for skin, emotional, and metabolic concerns:

• Hormonal and nervous system regulator: Reduces PMS symptoms, balances cortisol, and improves stress tolerance—often reflected in skin health.

• Supports liver detoxification: Aids in eliminating spent hormones and toxins that can cause breakouts.

• Anti-inflammatory: Reduces chronic inflammation, including inflammatory skin conditions like eczema and acne.

• Collagen and keratin synthesis: Promotes the health of connective tissues, nails, hair, and skin.

• Mood and sleep enhancer: Supports serotonin and melatonin production, key for emotional and skin balance.

What are the benefits of Pyridoxal 5’-Phosphate ?

✔ Balances hormonal imbalances and their skin effects
✔ Calms skin prone to hormonal or stress-related acne
✔ Promotes liver detoxification
✔ Supports energy production and overall vitality
✔ Aids in collagen synthesis for firmer, glowing skin

How to consume or use Pyridoxal 5’-Phosphate ?

P-5-P is primarily used as a dietary supplement:

• Recommended dose: Between 10 and 50 mg per day, depending on individual needs (stress, hormonal issues, fatigue, acne, etc.)

• Combined formulations: Often paired with magnesium, taurine, or zinc to enhance its nervous system and skin benefits.

• Cosmetic use (emerging): Some dermocosmetic formulas are beginning to include P-5-P for its anti-inflammatory and soothing properties.

⚠️ Always consult a healthcare provider before supplementing, especially if pregnant or on medication.

Any side effects ?

P-5-P is generally very well tolerated:

• Rare side effects at normal doses

• At high doses (>100 mg/day), may cause tingling or reversible paresthesia

• Possible interactions with certain medications (especially anti-epileptics)

Scientific Sources

• Skin and pigmentation: B6 (incl. PLP) prevents melanosome phagocytosis by keratinocytes via Nrf2 activation, reducing pigment spots – jstage.jst.go.jp

• Systemic role: PLP plays a central role in cellular metabolism, oxidative stress, immunity, and homeostasis – en.wikipedia.org, lpi.oregonstate.edu, cosmeticsinfo.org

• Inflammation regulator and skin biomarkers: Low PLP levels are linked to high inflammatory markers. Increased P5P reduces PYGL and G6PD enzyme activation involved in skin inflammation – sciencedirect.com, consensus.app