3-in-1 native collagen supplement

As menopause approaches, the decline in estrogen goes far beyond hot flashes. It triggers a cascade of metabolic losses that directly impact 3 pillars of your body's structure: your bones, joints, and skin—all linked to the loss of connective tissue mass.

Bone mineral density can decline by up to 20% in the 5 to 7 years following menopause [1], skin collagen production drops by up to 30% in the first 5 years [2], and joint cartilage, stripped of its hormonal protection, gradually thins [3].

These three phenomena often happen in parallel, with joint stiffness frequently being the first "visible" sign.

[MY] Essentials Bones, Skin & Joints was formulated to counteract these metabolic losses, and also for those who want to take preventive action before these losses become permanent.

AT THE HEART OF OUR FORMULA

• A native vegetarian collagen of exceptional quality to restore tissue density from within

Collagen derived from egg shell membrane (Ovomet® - Ovoderm® - EGGNOVO Laboratory): 300mg per daily dose, which is the dose validated by research (including 66mg of Type I, V and X collagen, 75mg of elastin, 9mg of hyaluronic acid, 6mg of glucosamine, 6mg of chondroitin, measured and guaranteed by Eggnovo [4])

A native collagen different from "conventional" collagens: Marine and bovine collagens are extracts of hydrolyzed peptides (Type I and II only) that your body must digest, transform, and then reassemble. To achieve measurable results, daily intakes of 5g to 10g are necessary, with results appearing between 8 to 12 weeks.
Ovomet®/Ovoderm®, by contrast, is effective at just 300mg/day because it is native and therefore far more bioavailable and recognizable by your body (absorbable with clinical results visible in just 5 days).

The absorbed fraction of Ovomet®/Ovoderm® at 90-100% stimulates your body's endogenous synthesis of collagen and hyaluronic acid, and inhibits the enzymes responsible for collagen and elastin breakdown. Its non-digestible fraction (50%) acts as a prebiotic, helping to rebalance your microbiome and reduce low-grade systemic inflammation, often the root cause of chronic joint stiffness.

Clinical results at the exact dose in our formula (300mg/day) [4]:

Clinical studies conducted at 300mg per day showed significant results on joints in just 5 days vs. placebo, with pain reduction up to -47% and stiffness reduction up to -68%.
On tendons, elasticity improved by +37% to +46% after 50 days vs. placebo.
On skin, elasticity improved by +18 to +26%, firmness by +14 to +21%, and transepidermal water loss was reduced by -18% to -35% vs. placebo after 60 days [4].

• Ceramides from wheat proteins to restore your skin barrier from within

Ceramides are the structural lipids of your skin's superficial layer (the stratum corneum), where they play a central role in water retention and protection against external stressors.

At menopause, the drop in estrogen directly disrupts their production: the stratum corneum of menopausal women shows significantly lower ceramide levels, with reduced molecular chain length. Changes directly correlated to hormonal decline, not just chronological aging [7]. These alterations increase water loss, making skin more reactive, drier, and more vulnerable.

Ceramide supplementation helps restore the integrity of this barrier, reduce water loss, and improve skin comfort and radiance from within [7].

• Patented polyphenol complex Bonolive®: for bone formation, joint comfort, and skin quality

Bonolive® (olive leaf extract, Olea europaea): 250mg per daily dose standardized to minimum 40% oleuropein

Bonolive® was developed specifically to support the health of women in peri- and post-menopause. To date, it is one of the rare patented actives to have clinically demonstrated simultaneous action on bone formation, joint comfort, lipid balance, and skin quality—all at a dose of just 250mg per day.

Its mechanism of action is cellular: oleuropein stimulates the differentiation of stem cells into osteoblasts (the cells responsible for bone formation), while slowing their transformation into adipocytes—an imbalance that naturally accelerates as estrogen declines. At the joint level, its powerful antioxidant activity helps reduce markers of inflammation and cartilage degradation [8][9][10].

What clinical studies have shown:
In a randomized, double-blind trial over 12 months in 64 osteopenic menopausal women, Bonolive® at 250mg/day led to a +32% increase in osteocalcin levels (the benchmark marker for bone formation), while the placebo group showed a -6% decline!
Lumbar bone mineral density was maintained in the Bonolive® group, while it decreased by -1.9% in the placebo group.
A significant reduction in total cholesterol (-11%), LDL (-21%), and triglycerides was also observed [8].

On joints, a randomized multi-center study over 6 months in 124 people suffering from moderate knee pain showed a -46% reduction in overall joint discomfort score in the subgroup with high walking-related pain, with improved comfort in daily activities [9].

On skin, a study published in 2025 in 65 menopausal women observed stabilization of skin elastin in the Bonolive® group, where it declined in the placebo group, as well as a reduction in a key marker of protein aging (pentosidine) and a significant improvement in skin texture and pore count after 8 to 12 weeks [10]

• Coenzyme Q10 and Vitamin C: an antioxidant synergy to protect, regenerate, and stimulate collagen production

Coenzyme Q10 is naturally produced by your body, but its synthesis declines with age. It helps protect your cells from oxidative stress and plays a role in cellular energy production in cartilage cells, supporting their capacity for regeneration [11].

Vitamin C is an essential cofactor for normal collagen synthesis, contributing to the normal function of your skin, bones, and cartilage [12].

Together, these two antioxidants help protect your cells from oxidative stress [13].

• Structural cofactors for a comprehensive formula

• Bamboo (Bambusa vulgaris) provides bioavailable silica, which supports Type I collagen synthesis and bone mineralization.
• Calcium Citrate is well-tolerated digestively and contributes to bone strength.
• Vitamins K2 & D3 contribute to normal calcium metabolism and its direction toward bone, helping preserve bone density.
• Zinc Bisglycinate is essential for collagen matrix synthesis, bone mineralization, and bone tissue renewal. Zinc bisglycinate shows 43% superior bioavailability compared to conventional forms like zinc gluconate.

WHAT MAKES IT DIFFERENT

• Triple targeted action for bone density, skin, and joint comfort in just 3 capsules per day
• Collagen effective at just 300mg/day, with clinical results in 5 days (compared to conventional collagens requiring 5 to 10g/day for 12 weeks)
• Highly bioavailable native collagen: naturally contains 3 types of peptides (I, V and X) plus hyaluronic acid, elastin, glucosamine, and chondroitin—unlike hydrolyzed extracts (marine and bovine)
• Two clinically studied patented actives: vegetarian collagen from egg shell membrane Ovomet®/Ovoderm® & polyphenol complex Bonolive®
• Calcium citrate and zinc bisglycinate: forms with superior bioavailability compared to conventional forms
• Vitamin D3 from lichen, suitable for vegetarian diets
• Antioxidant synergy: Coenzyme Q10 + Vitamin C
• Vegetable capsule

SOURCES

[1] Rani et al. (2023). Accelerated bone loss at menopause and increased risk of postmenopausal osteoporosis. Indian Journal of Orthopaedics, 57(Suppl 1), 105-114. https://doi.org/10.1007/s43465-023-01071-6

[2] Duangjai et al. (2025). Randomized controlled study on calcium, vitamin D, and collagen supplementation in menopausal women. Clinics and Practice, 15(9), 168. https://doi.org/10.3390/clinpract15090168

[3] Roman-Blas et al. (2009). Link between estrogen deficiency and joint cartilage degradation. Arthritis Research & Therapy, 11(5), 241. https://doi.org/10.1186/ar2791

[4] Eggnovo. Official ingredient data sheets for Ovomet® and Ovoderm®, data measured and guaranteed by Eggnovo laboratory.

[5] Iwai et al. (2005) & Ohara et al. (2007). Plasma bioavailability of Pro-Hyp peptide after ingestion of hydrolyzed collagen. J. Agric. Food Chem., 53(16) & 55(4). https://doi.org/10.1021/jf050206p and https://doi.org/10.1021/jf062834s

[6] Actives & Co. Technical data sheets on the mechanisms of action of oral collagen.

[7] Kendall et al. (2022). Reduction of ceramides in the stratum corneum of menopausal women, correlated with estrogen decline. Scientific Reports, 12. https://doi.org/10.1038/s41598-022-26095-0

[8] Filip et al. (2015). Randomized double-blind trial of Bonolive® in 64 osteopenic menopausal women: +32% osteocalcin vs. -6% placebo, stabilization of lumbar BMD, improvement in lipid profile. The Journal of Nutrition, Health & Aging, 19(1), 77-86. https://doi.org/10.1007/s12603-014-0480-x

[9] Horcajada et al. (2022). Randomized multi-center trial of Bonolive®: -46% reduction in KOOS score in 124 people with moderate knee pain. Therapeutic Advances in Musculoskeletal Disease, 14, 1759720X211070205. https://doi.org/10.1177/1759720X211070205

[10] Lasfar et al. (2025). Randomized double-blind trial of Bonolive® in 65 menopausal women: stabilization of skin elastin, reduction in pentosidine, improvement in skin texture. Frontiers in Nutrition, 12, 1670194. https://doi.org/10.3389/fnut.2025.1670194

[11] Bentinger et al. (2007). Role of coenzyme Q10 as a mitochondrial antioxidant, with production declining with age. Mitochondrion, 7, S41-S50. https://doi.org/10.1016/j.mito.2007.02.006

[12] Pullar et al. (2017). Vitamin C, an essential cofactor for skin collagen synthesis. Nutrients, 9(8), 866. https://doi.org/10.3390/nu9080866

[13] Arkan Yousif et al. (2025). Synergistic effect of coenzyme Q10 and vitamin C on skin. Journal of Cosmetic Dermatology, 24(1), e16706. https://doi.org/10.1111/jocd.16706

[14] Reffitt et al. (2003). Stimulation of Type I collagen synthesis and osteoblast differentiation by orthosilicic acid. Bone, 32(2), 127-135. https://doi.org/10.1016/S8756-3282(02)00950-X

[15] Jugdaohsingh R. (2007). Positive associations between silicon intake and bone mineral density in large cohorts. The Journal of Nutrition, Health & Aging, 11(2), 99-110. https://pmc.ncbi.nlm.nih.gov/articles/PMC2658806/

[16] Sakhaee et al. (1988). Meta-analysis of 15 studies: superior bioavailability of calcium citrate vs. carbonate by 22 to 27%. Journal of Bone and Mineral Research, 3(3), 253.

[17] Aaseth et al. (2024). The association of vitamins K2 and D3 contributes to calcium metabolism and preservation of bone density. Nutrients, 16(15), 2420. https://doi.org/10.3390/nu16152420

[18] Molenda & Kolmas (2023). Zinc, a key micronutrient for bone health and collagen synthesis. Biological Trace Element Research. https://doi.org/10.1007/s12011-023-03631-1

[19] Gandia et al. (2007). Superior bioavailability of zinc bisglycinate by 43.4% vs. zinc gluconate. International Journal for Vitamin and Nutrition Research, 77(4), 243. https://doi.org/10.1024/0300-9831.77.4.243

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